Tove is interested in the genetic architecture of metabolic diseases and its interaction with environmental factors. She is also interested in the heterogeneity of the type 2 diabetes phenotype. Her doctoral research described several different subtypes of diabetes in the dog, a species that was earlier described to have a single form of the syndrome. She has also led the work of performing a GWAS in pure-bred elkhounds affected by gestational diabetes. Tove is involved in the ENGAGE flagship project called ‘Large-scale genotyping of selected causal variants’. The scientific aims of this projects are to obtain very large-scale data on a limited number of SNPs for evaluation of causal pathways using a Mendelian randomization design, estimations of pleiotropic effects of selected genetic loci as well as joint effects of genes and environment.

Webpage: Dept of Medical Epidemiology and Biostatistics, Karolinska Institutet