PRESS AND PUBLICATIONS
All the publications below acknowledge ENGAGE funding
European Community's Seventh Framework Programme (FP7/2007-2013); Grant Agreement HEALTH-F4-2007- 201413
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'European Netwok for Genetic and Genomic Epidemiology-ENGAGE video
2014
Albrecht E, et al., Telomere length in circulating leukocytes is associated with lung function and disease. Eur Respir J. 2014 Apr;43(4):983-92. doi: 10.1183/09031936.00046213. Epub 2013 Dec 5.
Arking DE et al., Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet. 2014 Aug;46(8):826-36. doi: 10.1038/ng.3014. Epub 2014 Jun 22.
Bolton JL, et al., Genome Wide Association Identifies Common Variants at the SERPINA6/SERPINA1 Locus Influencing Plasma Cortisol and Corticosteroid Binding Globulin. PLoS Genet. 2014 Jul 10;10(7):e1004474. doi: 10.1371/journal.pgen.1004474. eCollection 2014 Jul.
Boraska V et al., A genome-wide association study of anorexia nervosa. Mol Psychiatry. 2014 Feb 11. doi: 10.1038/mp.2013.187. [Epub ahead of print]
Broer L, et al., Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants. Eur J Epidemiol. 2014 Sep;29(9):629-38. doi: 10.1007/s10654-014-9940-1. Epub 2014 Jul 27.
Budin-Ljøsne I, Isaeva J, Knoppers BM, Tassé AM, Shen HY, McCarthy MI, Harris JR; ENGAGE Consortium. Data sharing in large research consortia: experiences and recommendations from ENGAGE. Eur J Hum Genet. 2014 Mar;22(3):317-21. doi: 10.1038/ejhg.2013.131. Epub 2013 Jun 19.
Cousminer DL et al., Widén E; for the Early Growth Genetics (EGG) Consortium. Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty. Hum Mol Genet. 2014 Aug 15;23(16):4452-64. doi: 10.1093/hmg/ddu150. Epub 2014 Apr 25.
Deelen J et al., Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers. Int J Epidemiol. 2014 Jun;43(3):878-86. doi: 10.1093/ije/dyt267. Epub 2014 Jan 14
Dichgans M et al.,; METASTROKE Consortium; CARDIoGRAM Consortium; C4D Consortium; International Stroke Genetics Consortium. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. 2014 Jan;45(1):24-36. doi: 10.1161/STROKEAHA.113.002707. Epub 2013 Nov 21. Review.
Falchi M, et al., Low copy number of the salivary amylase gene predisposes to obesity. Nat Genet. 2014 May;46(5):492-7. doi: 10.1038/ng.2939. Epub 2014 Mar 30.
Fall T, Ingelsson E. Genome-wide association studies of obesity and metabolic syndrome. Mol Cell Endocrinol. 2014 Jan 25;382(1):740-57. doi: 10.1016/j.mce.2012.08.018. Epub 2012 Sep 3. Review.
Faulconbridge A, Burdett T, Brandizi M, Gostev M, Pereira R, Vasant D, Sarkans U, Brazma A, Parkinson H. Updates to BioSamples database at European Bioinformatics Institute. Nucleic Acids Res. 2014 Jan;42(Database issue):D50-2. doi: 10.1093/nar/gkt1081. Epub 2013 Nov 21.
Ferrario MM, Veronesi G, Chambless LE, Tunstall-Pedoe H, Kuulasmaa K, Salomaa V, Borglykke A, Hart N, Söderberg S, Cesana G; MORGAM Project. The contribution of educational class in improving accuracy of cardiovascular risk prediction across European regions: The MORGAM Project Cohort Component. Heart. 2014 Aug 1;100(15):1179-87. doi: 10.1136/heartjnl-2013-304664. Epub 2014 May 1.
Fischer K, Kettunen J, Würtz P, Haller T, Havulinna AS, Kangas AJ, Soininen P, Esko T, Tammesoo ML, Mägi R, Smit S, Palotie A, Ripatti S, Salomaa V, Ala-Korpela M, Perola M, Metspalu A. Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons. PLoS Med. 2014 Feb 25;11(2):e1001606. doi: 10.1371/journal.pmed.1001606. eCollection 2014 Feb.
Flannick J et al., Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet. 2014 Apr;46(4):357-63. doi: 10.1038/ng.2915. Epub 2014 Mar 2.
He L, Sillanpää MJ, Ripatti S, Pitkäniemi J. Bayesian latent variable collapsing model for detecting rare variant interaction effect in twin study. Genet Epidemiol. 2014 May;38(4):310-24. doi: 10.1002/gepi.21804. Epub 2014 Apr 9.
Herder C, Nuotio ML, Shah S, Blankenberg S, Brunner EJ, Carstensen M, Gieger C, Grallert H, Jula A, Kähönen M, Kettunen J, Kivimäki M, Koenig W, Kristiansson K, Langenberg C, Lehtimäki T, Luotola K, Marzi C, Müller C, Peters A, Prokisch H, Raitakari O, Rathmann W, Roden M, Salmi M, Schramm K, Swerdlow D, Tabak AG, Thorand B, Wareham N, Wild PS, Zeller T, Hingorani AD, Witte DR, Kumari M, Perola M, Salomaa V. Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits. Diabetes. 2014 Jun 26. pii: DB_140731. [Epub ahead of print]
Jansen R, Batista S, Brooks AI, Tischfield JA, Willemsen G, van Grootheest G, Hottenga JJ, Milaneschi Y, Mbarek H, Madar V, Peyrot W, Vink JM, Verweij CL, de Geus EJ, Smit JH, Wright FA, Sullivan PF, Boomsma DI, Penninx BW. Sex differences in the human peripheral blood transcriptome. BMC Genomics. 2014 Jan 17;15:33. doi: 10.1186/1471-2164-15-33.
König IR, Loley C, Erdmann J, Ziegler A. How to include chromosome X in your genome-wide association study. Genet Epidemiol. 2014 Feb;38(2):97-103. doi: 10.1002/gepi.21782. Epub 2014 Jan 9.
Lim ET et al., Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. PLoS Genet. 2014 Jul 31;10(7):e1004494. doi: 10.1371/journal.pgen.1004494. eCollection 2014 Jul.
Loth DW, et al., Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet. 2014 Jul;46(7):669-77. doi: 10.1038/ng.3011. Epub 2014 Jun 15
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium; Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium; South Asian Type 2 Diabetes (SAT2D) Consortium; Mexican American Type 2 Diabetes (MAT2D) Consortium; Type 2 Diabetes Genetic Exploration by Nex-generation sequencing in muylti-Ethnic Samples (T2D-GENES) Consortium, Mahajan A, et al., Consortium.Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet. 2014 Mar;46(3):234-44. doi: 10.1038/ng.2897. Epub 2014 Feb 9.
Marttinen P, Pirinen M, Sarin AP, et al., Assessing multivariate gene-metabolome associations with rare variants using Bayesian reduced rank regression. Bioinformatics. 2014 Jul 15;30(14):2026-34. doi: 10.1093/bioinformatics/btu140. Epub 2014 Mar 24.
Medici M et al., Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genet. 2014 Feb 27;10(2):e1004123. doi: 10.1371/journal.pgen.1004123. eCollection 2014 Feb.
Naukkarinen J, Heinonen S, Hakkarainen A, Lundbom J, Vuolteenaho K, Saarinen L, Hautaniemi S, Rodriguez A, Frühbeck G, Pajunen P, Hyötyläinen T, Oreši? M, Moilanen E, Suomalainen A, Lundbom N, Kaprio J, Rissanen A, Pietiläinen KH. Characterising metabolically healthy obesity in weight-discordant monozygotic twins. Diabetologia. 2014 Jan;57(1):167-76. doi: 10.1007/s00125-013-3066-y. Epub 2013 Oct 8.
Pasquali L, Gaulton KJ, Rodríguez-Seguí SA, Mularoni L, Miguel-Escalada I, Akerman I, Tena JJ, Morán I, Gómez-Marín C, van de Bunt M, Ponsa-Cobas J, Castro N, Nammo T, Cebola I, García-Hurtado J, Maestro MA, Pattou F, Piemonti L, Berney T, Gloyn AL, Ravassard P, Gómez-Skarmeta JL, Müller F, McCarthy MI, Ferrer J. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat Genet. 2014 Feb;46(2):136-43. doi: 10.1038/ng.2870. Epub 2014 Jan 12.
Peltekova VD, Lemire M, Qazi AM, Zaidi SH, Trinh QM, Bielecki R, Rogers M, Hodgson L, Wang M, D'Souza DJ, Zandi S, Chong T, Kwan JY, Kozak K, De Borja R, Timms L, Rangrej J, Volar M, Chan-Seng-Yue M, Beck T, Ash C, Lee S, Wang J, Boutros PC, Stein LD, Dick JE, Gryfe R, McPherson JD, Zanke BW, Pollett A, Gallinger S, Hudson TJ. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants. Int J Cancer. 2014 May 15;134(10):2330-41. doi: 10.1002/ijc.28557. Epub 2013 Nov 13.
Petersen AK, Zeilinger S, Kastenmüller G, Römisch-Margl W, Brugger M, Peters A, Meisinger C, Strauch K, Hengstenberg C, Pagel P, Huber F, Mohney RP, Grallert H, Illig T, Adamski J, Waldenberger M, Gieger C, Suhre K. Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits. Hum Mol Genet. 2014 Jan 15;23(2):534-45. doi: 10.1093/hmg/ddt430. Epub 2013 Sep 6.
Pirastu N, Kooyman M, Traglia M, Robino A, Willems SM, Pistis G, d'Adamo P, Amin N, d'Eustacchio A, Navarini L, Sala C, Karssen LC, van Duijn C, Toniolo D, Gasparini P. Association analysis of bitter receptor genes in five isolated populations identifies a significant correlation between TAS2R43 variants and coffee liking. PLoS One. 2014 Mar 19;9(3):e92065. doi: 10.1371/journal.pone.0092065. eCollection 2014.
Power RA, Keller MC, Ripke S, Abdellaoui A, Wray NR, Sullivan PF; MDD PGC Working Group, Breen G. A recessive genetic model and runs of homozygosity in major depressive disorder. Am J Med Genet B Neuropsychiatr Genet. 2014 Mar;165B(2):157-66. doi: 10.1002/ajmg.b.32217. Epub 2014 Jan 30.
Prokopenko I, Poon W, Mägi R, et al., A central role for GRB10 in regulation of islet function in man. PLoS Genet. 2014 Apr 3;10(4):e1004235. doi: 10.1371/journal.pgen.1004235. eCollection 2014 Apr.
Rietveld CA, Esko T, et al., Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13790-4. doi: 10.1073/pnas.1404623111. Epub 2014 Sep 8.
Saxena R, Bjonnes A, Prescott J, Dib P, Natt P, Lane J, Lerner M, Cooper JA, Ye Y, Li KW, Maubaret CG, Codd V, Brackett D, Mirabello L, Kraft P, Dinney CP, Stowell D, Peyton M, Ralhan S, Wander GS, Mehra NK, Salpea KD, Gu J, Wu X, Mangino M, Hunter DJ, De Vivo I, Humphries SE, Samani NJ, Spector TD, Savage SA, Sanghera DK. Genome-wide association study identifies variants in casein kinase II (CSNK2A2) to be associated with leukocyte telomere length in a Punjabi Sikh diabetic cohort. Circ Cardiovasc Genet. 2014 Jun;7(3):287-95. doi: 10.1161/CIRCGENETICS.113.000412. Epub 2014 May 3.
Service SK, Teslovich TM, Fuchsberger C, et al., Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci. PLoS Genet. 2014 Jan 0;10(1):e1004147. doi: 10.1371/journal.pgen.1004147. eCollection 2014 Jan
van den Berg SM, de Moor MH, et al., Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet. 2014 Jul;44(4):295-313. doi: 10.1007/s10519-014-9654-x. Epub 2014 May 15
Vasan SK, Karpe F, Gu HF, Brismar K, Fall CH, Ingelsson E, Fall T. FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. Obesity (Silver Spring). 2014 Mar;22(3):964-70. doi: 10.1002/oby.20606. Epub 2013 Sep 20.
Vimaleswaran KS et al., Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol. 2014 Jun 25. pii: S2213-8587(14)70113-5. doi: 10.1016/S2213-8587(14)70113-5. [Epub ahead of print]
Vishram JK et al, Do other cardiovascular risk factors influence the impact of age on the association between blood pressure and mortality? The MORGAM Project. J Hypertens. 2014 May;32(5):1025-32; discussion 1033. doi: 10.1097/HJH.0000000000000133.
Vishram JK et al., Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project. PLoS One. 2014 Sep 22;9(9):e107294. doi: 10.1371/journal.pone.0107294. eCollection 2014.
Walsh KM, Codd V, et al., ENGAGE Consortium Telomere Group, van der Harst P, Wiencke JK, Samani NJ, Jenkins RB, Wrensch MR. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul;46(7):731-5. doi: 10.1038/ng.3004. Epub 2014 Jun 8.
Williams FM et al., Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol. 2013 Jan;73(1):16-31. doi: 10.1002/ana.23838. Erratum in: Ann Neurol. 2014 Jan;75(1):166-7.
Wright FA, Sullivan PF, Brooks AI, Zou F, Sun W, Xia K, Madar V, Jansen R, Chung W, Zhou YH, Abdellaoui A, Batista S, Butler C, Chen G, Chen TH, D'Ambrosio D, Gallins P, Ha MJ, Hottenga JJ, Huang S, Kattenberg M, Kochar J, Middeldorp CM, Qu A, Shabalin A, Tischfield J, Todd L, Tzeng JY, van Grootheest G, Vink JM, Wang Q, Wang W, Wang W, Willemsen G, Smit JH, de Geus EJ, Yin Z, Penninx BW, Boomsma DI. Heritability and genomics of gene expression in peripheral blood. Nat Genet. 2014 May;46(5):430-7. doi: 10.1038/ng.2951. Epub 2014 Apr 13.
2013
Abdellaoui A, Hottenga JJ, et al., Population structure, migration, and diversifying selection in the Netherlands.Eur J Hum Genet. 2013 Nov;21(11):1277-85. doi: 10.1038/ejhg.2013.48. Epub 2013 Mar 27.
Abdellaoui A, Hottenga JJ, et al., Association between autozygosity and major depression: stratification due to religious assortment. Behav Genet. 2013 Nov;43(6):455-67. doi: 10.1007/s10519-013-9610-1. Epub 2013 Aug 25.
Ahlqvist E et al., A link between GIP and osteopontin in adipose tissue and insulin resistance. Diabetes. 2013 Jun;62(6):2088-94. doi: 10.2337/db12-0976. Epub 2013 Jan 24. (Epud ahead of print) doi: 10.2337/db12-0976
Aigner J, Villatoro S, Rabionet R, Roquer J, Jiménez-Conde J, Martí E, Estivill X. A common 56-kilobase deletion in a primate-specific segmental duplication creates a novel butyrophilin-like protein. BMC Genet. 2013 Jul 6;14:61. doi: 10.1186/1471-2156-14-61.
Albrechtsen A et al, Exome sequencing-driven discovery of variants associated with common metabolic phenotypes. Diabetologia 56;298-310,2013. doi: 10.1007/s00125-012-2756-1
Anttila V, Winsvold BS et al, Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet. Nat Genet. 2013 Aug;45(8):912-7. doi: 10.1038/ng.2676. Epub 2013 Jun 23
Bassaganyas L, Riveira-Muñoz E, García-Aragonés M, González JR, Cáceres M, Armengol L, Estivill X. Worldwide population distribution of the common LCE3C-LCE3B deletion associated with psoriasis and other autoimmune disorders. BMC Genomics. 2013 Apr 17;14:261. doi: 10.1186/1471-2164-14-261.
Beekman M, et al., Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study. Aging Cell. 2013 Apr;12(2):184-93. doi: 10.1111/acel.12039. Epub 2013 Feb 6.
Berndt SI et al, Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013 May;45(5):501-12. doi: 10.1038/ng.2606. Epub 2013 Apr 7.
Budin-Ljøsne I, Soye KJ, Tassé AM, Knoppers BM, Harris JR. Genotype-driven recruitment: a strategy whose time has come? BMC Med Genomics. 2013 May 23;6:19. doi: 10.1186/1755-8794-6-19.
Broer L et al. Meta-analysis of telomere length in 19_713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect. Eur J Hum Genet. 2013 Jan 16. doi: 10.1038/ejhg.2012.303. [Epub ahead of print] doi: 10.1038/ejhg.2012.303
Cecelja M, Frost ML, Spector TD, Chowienczyk P. Abdominal aortic calcification detection using dual-energy X-ray absorptiometry: validation study in healthy women compared to computed tomography. Calcif Tissue Int. 2013 Jun;92(6):495-500. doi: 10.1007/s00223-013-9704-z. Epub 2013 Feb 14.
Cecelja M, Hussain T, Greil G, Botnar R, Preston R, Moayyeri A, Spector TD, Chowienczyk P. Multimodality imaging of subclinical aortic atherosclerosis: relation of aortic stiffness to calcification and plaque in female twins. Hypertension. 2013 Mar;61(3):609-14. doi: 10.1161/HYPERTENSIONAHA.111.00024. Epub 2013 Jan 21.
Codd V, Nelson C, Albrecht E et al. Identification of seven loci affecting mean telomere length and their association with disease. Nat Genet. 2013 Apr;45(4):422-7. doi: 10.1038/ng.2528 (ENGAGE Flagship Project Paper)
Cordell HJ, et al., Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. Hum Mol Genet. 2013 Apr 1;22(7):1473-81. doi: 10.1093/hmg/dds552. Epub 2013 Jan 7.
Cousminer DL, et al., Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. Hum Mol Genet. 2013 Jul 1;22(13):2735-47. doi: 10.1093/hmg/ddt104. Epub 2013 Feb 27.
Couto Alves A, Bruhn S, Ramasamy A, Wang H, Holloway JW, Hartikainen AL, Jarvelin MR, Benson M, Balding DJ, Coin LJ. Dysregulation of complement system and CD4+ T cell activation pathways implicated in allergic response. PLoS One. 2013 Oct 8;8(10):e74821. doi: 10.1371/journal.pone.0074821. eCollection 2013.
CARDIoGRAMplusC4D Consortium, Deloukas P, et al., Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013 Jan;45(1):25-33. doi: 10.1038/ng.2480. Epub 2012 Dec 2
Demirkan A, Isaacs A, Ugocsai P, Liebisch G, Struchalin M, Rudan I, Wilson JF, Pramstaller PP, Gyllensten U, Campbell H, Schmitz G, Oostra BA, van Duijn CM. Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study. J Psychiatr Res. 2013 Mar;47(3):357-62. doi: 10.1016/j.jpsychires.2012.11.001. Epub 2012 Nov 30.
Erdmann J, et al., Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 2013 Dec 19;504(7480):432-6. doi: 10.1038/nature12722. Epub 2013 Nov 10
Escaramís G, Tornador C, Bassaganyas L, Rabionet R, Tubio JM, Martínez-Fundichely A, Cáceres M, Gut M, Ossowski S, Estivill X. PeSV-Fisher: identification of somatic and non-somatic structural variants using next generation sequencing data. PLoS One. 2013 May 21;8(5):e63377. doi: 10.1371/journal.pone.0063377. Print 2013.
Esko T, et al., Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity. Eur J Hum Genet. 2013 Jun;21(6):659-65. doi: 10.1038/ejhg.2012.229. Epub 2012 Dec 19.
Fall T et al., Pedersen NL, McCarthy MI, Ingelsson E, Prokopenko I, for the European Network for Genetic and Genomic Epidemiology (ENGAGE) consortium. The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Med 10(6): e1001474. doi:10.1371/journal.pmed.1001474 (ENGAGE Flagship Project Paper).
Fatemifar G et al, Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances. Hum Mol Genet. 2013 Jun 5. [Epub ahead of print] doi: 10.1093/hmg/ddt231
Ganna A, Ortega-Alonso A, Havulinna A, Salomaa V, Kaprio J, Pedersen NL, Sullivan PF, Ingelsson E, Hultman CM, Magnusson PK. Utilizing twins as controls for non-twin case-materials in genome wide association studies. PLoS One. 2013 Dec 10;8(12):e83101. doi: 10.1371/journal.pone.0083101. eCollection 2013.
Ganna A, Rivadeneira F, Hofman A, Uitterlinden AG, Magnusson PKE, Pedersen NL, Ingelsson E, Tiemeier H. Genetic determinants of mortality. Can findings from genome-wide association studies explain variation in human mortality? Hum Genet. 2013 May;132(5):553-61. doi: 10.1007/s00439-013-1267-6. Epub 2013 Jan 25.
Gao, H et al., Evidence of a Causal Relationship between Adiponectin Levels and Insulin Sensitivity: A Mendelian Randomization Study. Diabetes. 2013 Apr;62(4):1338-44. doi: 10.2337/db12-0935.
Glass D, et al., Gene expression changes with age in skin, adipose tissue, blood and brain. Genome Biol. 2013 Jul 26;14(7):R75. doi: 10.1186/gb-2013-14-7-r75.
Grarup N, et al., Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLoS Genet. 2013 Jun;9(6):e1003530. doi: 10.1371/journal.pgen.1003530. Epub 2013 Jun 6.
Hek K, et al., A genome-wide association study of depressive symptoms.Biol Psychiatry. 2013 Apr 1;73(7):667-78. doi: 10.1016/j.biopsych.2012.09.033. Epub 2013 Jan 3.
Horikoshi M et al, New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet. 2013 Jan;45(1):76-82. doi: 10.1038/ng.2477. Epub 2012 Dec 2.
Jones GT et al., A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm. Hum Mol Genet. 2013 Jul 15;22(14):2941-7. doi: 10.1093/hmg/ddt141. Epub 2013 Mar 27.
Jonsson A, Ladenvall C, Ahluwalia TS, Kravic J, Krus U, Taneera J, Isomaa B, Tuomi T, Renström E, Groop L, Lyssenko V. Effects of common genetic variants associated with type 2 diabetes and glycemic traits on α- and β-cell function and insulin action in humans. Diabetes. 2013 Aug;62(8):2978-83. doi: 10.2337/db12-1627. Epub 2013 Apr 4.
Jonsson T, Stefansson H, Steinberg S, Jonsdottir I, Jonsson PV, Snaedal J, Bjornsson S, Huttenlocher J, Levey AI, Lah JJ, Rujescu D, Hampel H, Giegling I, Andreassen OA, Engedal K, Ulstein I, Djurovic S, Ibrahim-Verbaas C, Hofman A, Ikram MA, van Duijn CM, Thorsteinsdottir U, Kong A, Stefansson K. Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med. 2013 Jan 10;368(2):107-16. doi: 10.1056/NEJMoa1211103. Epub 2012 Nov 14.
Kaprio J. The Finnish Twin Cohort Study: an update. Twin Res Hum Genet. 2013 Feb;16(1):157-62. doi: 10.1017/thg.2012.142. Epub 2013 Jan 8. Review.
Khrunin AV, Khokhrin DV, Filippova IN, Esko T, Nelis M, Bebyakova NA, Bolotova NL, Klovins J, Nikitina-Zake L, Rehnström K, Ripatti S, Schreiber S, Franke A, Macek M, Krulišová V, Lubinski J, Metspalu A, Limborska SA. A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe. PLoS One. 2013;8(3):e58552. doi: 10.1371/journal.pone.0058552. Epub 2013 Mar 7.
Koller DL et al., Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women. J Bone Miner Res. 2013 Mar;28(3):547-58. doi: 10.1002/jbmr.1796.
Köttgen A, Albrecht E, et al., Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500. Epub 2012 Dec 23.
Kujala UM, et al., Long-term leisure-time physical activity and serum metabolome. Circulation. 2013 Jan 22;127(3):340-8. doi: 10.1161/CIRCULATIONAHA.112.105551. Epub 2012 Dec 20
Ladwig KH, Brockhaus AC, Baumert J, Lukaschek K, Emeny RT, Kruse J, Codd V, Häfner S, Albrecht E, Illig T, Samani NJ, Wichmann HE, Gieger C, Peters A. Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study. PLoS One. 2013 Jul 3;8(7):e64762. doi: 10.1371/journal.pone.0064762. Print 2013.
Lahti L, Torrente A, Elo LL, Brazma A, Rung J. A fully scalable online pre-processing algorithm for short oligonucleotide microarray atlases. Nucleic Acids Res. 2013 May 1;41(10):e110. doi: 10.1093/nar/gkt229. Epub 2013 Apr 5.
Lappalainen T, et al., Transcriptome and genome sequencing uncovers functional variation in humans. Nature. 2013 Sep 26;501(7468):506-11. doi: 10.1038/nature12531. Epub 2013 Sep 15.
Lopes MC, Hysi PG, Verhoeven VJ, Macgregor S, Hewitt AW, Montgomery GW, Cumberland P, Vingerling JR, Young TL, van Duijn CM, Oostra B, Uitterlinden AG, Rahi JS, Mackey DA, Klaver CC, Andrew T, Hammond CJ. Identification of a candidate gene for astigmatism. Invest Ophthalmol Vis Sci. 2013 Feb 1;54(2):1260-7. doi: 10.1167/iovs.12-10463.
Ma RC, et al., Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4. Diabetologia. 2013 Jun;56(6):1291-305. doi: 10.1007/s00125-013-2874-4. Epub 2013 Mar 27
Mabile L, Dalgleish R, Thorisson GA, Deschênes M, Hewitt R, Carpenter J, Bravo E, Filocamo M, Gourraud PA, Harris JR, Hofman P, Kauffmann F, Muñoz-Fernàndez MA, Pasterk M, Cambon-Thomsen A; BRIF working group. Quantifying the use of bioresources for promoting their sharing in scientific research. Gigascience. 2013 May 1;2(1):7. doi: 10.1186/2047-217X-2-7.
Menni C, Kastenmüller G, Petersen AK, Bell JT, Psatha M, Tsai PC, Gieger C, Schulz H, Erte I, John S, Brosnan MJ, Wilson SG, Tsaprouni L, Lim EM, Stuckey B, Deloukas P, Mohney R, Suhre K, Spector TD, Valdes AM. Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int J Epidemiol. 2013 Aug;42(4):1111-9. doi: 10.1093/ije/dyt094. Epub 2013 Jul 8.
Menzel S et al., HbA(2) levels in normal adults are influenced by two distinct genetic mechanisms. Br J Haematol 2013 Jan;160(1):101-5. PMID: 23043469.
Minic? CC, Dolan CV, Hottenga JJ, Willemsen G, Vink JM, Boomsma DI. The use of imputed sibling genotypes in sibship-based association analysis: on modeling alternatives, power and model misspecification. Behav Genet. 2013 May;43(3):254-66. doi: 10.1007/s10519-013-9590-1. Epub 2013 Mar 22.
Nilsen TS, Knudsen GP, Gervin K, Brandt I, Røysamb E, Tambs K, Orstavik R, Lyle R, Reichborn-Kjennerud T, Magnus P, Harris JR. The Norwegian Twin Registry from a public health perspective: a research update. Twin Res Hum Genet. 2013 Feb;16(1):285-95. doi: 10.1017/thg.2012.117. Epub 2012 Nov 28.
Ogbah Z, et al., Evaluation of PAX3 genetic variants and nevus number. Pigment Cell Melanoma Res. 2013 Sep;26(5):666-76. doi: 10.1111/pcmr.12130. Epub 2013 Jul 4.
Parsa A, et al., Common variants in Mendelian kidney disease genes and their association with renal function. J Am Soc Nephrol. 2013 Dec;24(12):2105-17. doi: 10.1681/ASN.2012100983. Epub 2013 Sep 12.
Peyrot WJ, Middeldorp CM, Jansen R, Smit JH, de Geus EJ, Hottenga JJ, Willemsen G, Vink JM, Virding S, Barragan I, Ingelman-Sundberg M, Sim SC, Boomsma DI, Penninx BW. Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. J Affect Disord. 2013 Mar 20;146(1):91-9. doi: 10.1016/j.jad.2012.08.044. Epub 2012 Sep 27.
Pistis G, Okonkwo SU, Traglia M, Sala C, Shin SY, Masciullo C, Buetti I, Massacane R, Mangino M, Thein SL, Spector TD, Ganesh S; CHARGE Consortium Hematology Working, Pirastu N, Gasparini P, Soranzo N, Camaschella C, Hart D, Green MR, Toniolo D. Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans. PLoS One. 2013 Jul 31;8(7):e69206. doi: 10.1371/journal.pone.0069206. Print 2013.
Porcu E, et al., A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function. PLoS Genet. 2013;9(2):e1003266. doi: 10.1371/journal.pgen.1003266. Epub 2013 Feb 7.
Raffler J, Römisch-Margl W, Petersen AK, Pagel P, Blöchl F, Hengstenberg C, Illig T, Meisinger C, Stark K, Wichmann HE, Adamski J, Gieger C, Kastenmüller G, Suhre K. Identification and MS-assisted interpretation of genetically influenced NMR signals in human plasma. Genome Med. 2013 Feb 15;5(2):13. doi: 10.1186/gm417. eCollection 2013.
Randall JC et al, Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genet. 2013 Jun;9(6):e1003500. doi: 10.1371/journal.pgen.1003500. Epub 2013 Jun 6.
Rietveld CA, Cesarini D, Benjamin DJ, Koellinger PD, De Neve JE, Tiemeier H, Johannesson M, Magnusson PK, Pedersen NL, Krueger RF, Bartels M. Molecular genetics and subjective well-being. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9692-7. doi: 10.1073/pnas.1222171110. Epub 2013 May 24.
Rietveld CA et al, GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013 Jun 21;340(6139):1467-71. doi: 10.1126/science.1235488. Epub 2013 May 30.
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium, Ripke S et al., A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013 Apr;18(4):497-511. doi: 10.1038/mp.2012.21. Epub 2012 Apr 3.
Rung J, Brazma A. Reuse of public genome-wide gene expression data. Nat Rev Genet. 2013 Feb;14(2):89-99 (Epub 2012 Dec 27.)
Rustici et al., ArrayExpress update--trends in database growth and links to data analysis tools. Nucleic Acids Res. 2013 Jan;41(Database issue):D987-90.. Epub 2012 Nov 27.
Sabater-Lleal M et al., Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17;128(12):1310-24. doi: 10.1161/CIRCULATIONAHA.113.002251. Epub 2013 Aug 22.
Stoll G et al., Deletion of TOP3β, a component of FMRP-containing mRNPs, contributes to neurodevelopmental disorders. Nat Neurosci. 2013 Sep;16(9):1228-37. doi: 10.1038/nn.3484. Epub 2013 Aug 4.
Suls A et al., De novo loss-of-function mutations in CHD2 cause a fever-sensitive myoclonic epileptic encephalopathy sharing features with Dravet syndrome. Am J Hum Genet. 2013 Nov 7;93(5):967-75. doi: 10.1016/j.ajhg.2013.09.017. Epub 2013 Oct 24.
't Hoen PA, Friedländer MR, Almlöf J, Sammeth M, Pulyakhina I, Anvar SY, Laros JF, Buermans HP, Karlberg O, Brännvall M; GEUVADIS Consortium, den Dunnen JT, van Ommen GJ, Gut IG, Guigó R, Estivill X, Syvänen AC, Dermitzakis ET, Lappalainen T. Reproducibility of high-throughput mRNA and small RNA sequencing across laboratories. Nat Biotechnol. 2013 Nov;31(11):1015-22. doi: 10.1038/nbt.2702. Epub 2013 Sep 15.
Thanabalasingham G et al., Mutations in HNF1A result in marked alterations of plasma glycan profile. Diabetes. 2013 Apr;62(4):1329-37. doi: 10.2337/db12-0880. Epub 2012 Dec 28.
Thorgeirsson TE, Gudbjartsson DF, Sulem P, Besenbacher S, Styrkarsdottir U, Thorleifsson G, Walters GB; TAG Consortium; Oxford-GSK Consortium; ENGAGE consortium, Furberg H, Sullivan PF, Marchini J, McCarthy MI, Steinthorsdottir V, Thorsteinsdottir U, Stefansson K. A common biological basis of obesity and nicotine addiction. Transl Psychiatry. 2013 Oct 1;3:e308. doi: 10.1038/tp.2013.81.
Thun GA et al., Causal and synthetic associations of variants in the SERPINA gene cluster with alpha1-antitrypsin serum levels. PLoS Genet. 2013;9(8):e1003585. doi: 10.1371/journal.pgen.1003585. Epub 2013 Aug 22.
Tikkanen E, Havulinna AS, Palotie A, Salomaa V, Ripatti S. Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease. Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2261-6. doi: 10.1161/ATVBAHA.112.301120. Epub 2013 Apr 18
van der Loos MJ et al., The molecular genetic architecture of self-employment. PLoS One. 2013 Apr 4;8(4):e60542. doi: 10.1371/journal.pone.0060542. Print 2013.
van Dongen J, Willemsen G, Chen WM, de Geus EJ, Boomsma DI. Heritability of metabolic syndrome traits in a large population-based sample. J Lipid Res. 2013 Oct;54(10):2914-23. doi: 10.1194/jlr.P041673. Epub 2013 Aug 5.
Verhoeven VJ et al, Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet. 2013 Mar;45(3):314-8. doi: 10.1038/ng.2554. Epub 2013 Feb 10.
Vimaleswaran KS et al., Genetic association analysis of vitamin D pathway with obesity traits. Int J Obes (Lond). 2013 Feb 5. doi: 10.1038/ijo.2013.6. [Epub ahead of print]
Westra HJ et al., Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. 2013 Oct;45(10):1238-43. doi: 10.1038/ng.2756. Epub 2013 Sep 8.
Willemsen G et al.,The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection. Twin Res Hum Genet. 2013 Feb;16(1):271-81. doi: 10.1017/thg.2012.140. Epub 2013 Jan 8.
Global Lipids Genetics Consortium, Willer CJ et al., Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013 Nov;45(11):1274-83. doi: 10.1038/ng.2797. Epub 2013 Oct 6
Zhernakova DV et al, DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and noncoding transcripts. PLoS Genet 9(6): e1003594. doi:10.1371/journal.pgen.1003594 (ENGAGE Flagship Project Paper)
Zilbauer M et al., Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions. Blood. 2013 Dec 12;122(25):e52-60. doi: 10.1182/blood-2013-05-503201. Epub 2013 Oct 24.
2012
Ali Khan A, Rodriguez A, Sebert S, Kaakinen M, Cauchi S, et al. (2012) The Interplay of Variants Near LEKR and CCNL1 and Social Stress in Relation to Birth Size. PLoS ONE 7(6): e38216. doi:10.1371/journal.pone.0038216
Amin N et al, Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry 2012 Nov;17(11):1116-29. PMID: 21876539
Billings LK et al, Impact of common variation in bone-related genes on type 2 diabetes and related traits. Diabetes. 2012 Aug;61(8):2176-86. Epub 2012 Jun 14.
Boraska V et al, Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits. Am J Med Genet B Neuropsychiatr Genet. 2012 Oct;159B(7):803-11. PMID: 22911880; PMCID: PMC3494378.
Boraska V et al., Genome-wide Meta-analysis of Common Variant Differences between Men and Women. Hum Mol Genet. 2012 Jul 27. [Epub ahead of print]
Boraska V et al., Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. PLoS One. 2012 Mar;7(3):e31369
Boutant M et al. (2012) Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity. PLoS ONE 7(5): e35810. doi:10.1371/journal.pone.0035810
Bradfield JP et al., A genome-wide association meta-analysis reveals new childhood obesity loci. Nature Genetics 2012; 44, 526-531. doi:10.1038/ng.2247 [Epub 08 April 2012]
Budin-Ljøsne I. A review of ethical frameworks for the disclosure of individual research results in population-based genetic and genomic research. Research Ethics. March 2012 8: 25-42, doi:10.1177/1747016111435576
Budin-Ljøsne I, Harris JR, Kaye J, Knoppers BM, Tassé AM, Bravo E, Cambon-Thomsen E, Eriksson M, Ohm Kyvik K, Litton J-E, Perola M and Rial-Sebbag E. ELSI challenges and strategies of national biobank infrastructures. Norsk Epidemiologi 2012; 21 (2): 155-160.
Cecelja M, Jiang B, Spector TD, Chowienczyk P. Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study. J Am Coll Cardiol. 2012 Jan 31;59(5):475-83. PubMed PMID: 22281250.
Chasman DI et al, Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function. Hum Mol Genet. 2012 Dec 15;21(24):5329-43. doi: 10.1093/hmg/dds369. Epub 2012 Sep 8.
Chew S et al, Copy number variation of the APC gene is associated with regulation of bone mineral density. Bone 2012 Nov;51(5):939-43. PMID: 22884971.
Clark C et al, A comparison of the whole genome approach of MeDIP-seq to the targeted approach of the Infinium HumanMethylation450 BeadChip(¨) for methylome profiling. PLoS One. 2012;7(11):e50233.Epub 2012 Nov 29.
Coviello AD et al, A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation. PLoS Genet 2012 Jul;8(7):e1002805. PMID: 22829776; PMCID: PMC3400553.
Dastani Z et al., Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45, 891 Individuals. PLoS Genet. 2012 Mar;8(3):e1002607. Epub 2012 Mar 29.
Davies RW et al., A genome wide association association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex. Circ Cardiovasc Genet. 2012 Apr 1;5(2):217-25. Epub 2012 Feb 7.
Dimas AS et al, Sex-biased genetic effects on gene regulation in humans. Genome Res. 2012 Nov 1. [Epub ahead of print] PubMed PMID: 22960374.
Docampo E et al, Association of Neurexin 3 polymorphisms with smoking behavior. Genes Brain Behav. 2012 Aug;11(6):704-11.Epub 2012 Jul 17.
Ekelund M et al, Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus. Diab Res Clin Practice 97;394-98,2012.doi: 10.1016/j.diabres.2012.04.020. Epub 2012 May 14.
Ellinghaus E et al, Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL. Invest Dermatol. 2012 Apr;132(4):1133-40. doi: 10.1038/jid.2011.415. Epub 2011 Dec 15.
Fagerholm E et al, FinnDiane Study Group. SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes. Diabetologia 2012 Sep;55(9):2386-93. doi: 10.1007/s00125-012-2587-0
Fall T, Ingelsson E. Genome-wide association studies of obesity and metabolic syndrome.Mol Cell Endocrinol. 2012 Sep 3. pii: S0303-7207(12)00413-3
Fall T et al, The role of obesity-related genetic loci in insulin sensitivity. Diabetic Medicine 2012 Jul;29(7) e62-e66(Epub : June 19 2012)
Fonseca NA, Rung J, Brazma A, Marioni JC. Tools for mapping high-throughput sequencing data. Bioinformatics. 2012 Dec 15;28(24):3169-77. Epub 2012 Oct 11.
Froguel P et al., A Genome-Wide Association Study Identifies rs2000999 as a Strong Genetic Determinant of Circulating Haptoglobin Levels. PLoS One 2012;7(3):e32327. Epub 2012 Mar 5. (IF 4.411)
Gaál EI et al., Intracranial Aneurysm Risk Locus 5q23.2 Is Associated with Elevated Systolic Blood Pressure. PLoS Genet. 2012 Mar;8(3):e1002563.
Gervin K et al, DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes. PLoS Genet. 2012 Jan;8(1):e1002454. doi: 10.1371/journal.pgen.1002454. Epub 2012 Jan 19.
Goek ON et al, Serum metabolite concentrations and decreased GFR in the general population. Am J Kidney Dis. 2012 Aug;60(2):197-206. doi: 10.1053/j.ajkd.2012.01.014. Epub 2012 Mar 30
Gostev M, Faulconbridge A, Brandizi M, Fernandez-Banet J, Sarkans U, Brazma A, Parkinson H. The BioSample Database (BioSD) at the European Bioinformatics Institute. Nucleic Acids Res. 2012 Jan;40(Database issue):D64-70. Epub 2011 Nov 16
Grundberg E et al, Mapping cis- and trans-regulatory effects across multiple tissues in twins. NatGenet. 2012 Sep 2;44(10):1084-1089. doi: 10.1038/ng.2394. Epub 2012 Sep 2. PubMed PMID: 22941192.
Hancock DB et al., Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. PLoS Genet. 2012 Dec;8(12):e1003098. doi: 10.1371/journal.pgen.1003098. Epub 2012 Dec 20.
Harris JR, Burton P, Knoppers BM, Lindpaintner K and al. Towards a roadmap in global biobanking for health. European Journal of Human Genetics. Eur J Hum Genet. 2012 Jun 20. doi: 10.1038/ejhg.2012.96. [Epub ahead of print]
Harris JR, Haugan A, Budin-Lj¿sne I. Biobanking: from vision to reality. Norsk Epidemiologi 2012; 21 (2): 127-133
Hartz SM et al., Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers. Arch Gen Psychiatry. 2012 Aug;69(8):854-60. doi: 10.1001/archgenpsychiatry.2012.124.
Helgadottir A et al., Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol. 2012 Aug 21;60(8):722-9. doi: 10.1016/j.jacc.2012.01.078.
Hoggart CJ, O'Reilly PF, Kaakinen M, Zhang W, Chambers JC, Kooner JS, Coin LJ, Järvelin M-R. Fine-scale estimation of location of birth from genome-wide single-nucleotide polymorphism data. Genetics Feb, 2012;190(2):669-77. Epub 2011 Nov 17.
Huang J et al, Genome-wide association study for circulating levels of plasminogen activator inhibitor-1 (PAI-1) provides novel insights into the regulation of PAI-1. Blood 2012 Dec 6;120(24):4873-81. PMID: 22990020.
Hughes MF, Saarela O, Stritzke J, Kee F, Silander K, et al. (2012) Genetic Markers Enhance Coronary Risk Prediction in Men: The MORGAM Prospective Cohorts. PLoS ONE 7(7): e40922. doi:10.1371/journal.pone.0040922
Ikram MA et al. Common variants at 6q22 and 17q21 are associated with intracranial volume. Nat Genet. 2012 Apr 15;44(5):539-44. doi: 10.1038/ng.2245. [Epub ahead of print]
Kaakinen M et al, Associations between Variation in CHRNA5-CHRNA3-CHRNB4, Body Mass Index and Blood Pressure in the Northern Finland Birth Cohort 1966. PLoS One. 2012;7(9):e46557. doi: 10.1371/journal.pone.0046557. Epub 2012 Sep 27.
Kantomaa MT et al, Physical activity and obesity mediate the association between childhood motor function and adolescents' academic achievement. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1917-22. doi: 10.1073/pnas.1214574110. Epub 2012 Dec 31
Kettunen J, et al.,. Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Nat Genet. 2012 Jan 29;44(3):269-76. doi: 10.1038/ng.1073.
Kristiansson K et al., Genome-Wide Screen for Metabolic Syndrome Susceptibility Loci Reveals Strong Lipid Gene Contribution but No Evidence for Common Genetic Basis for Clustering of Metabolic Syndrome Traits. Circ Cardiovasc Genet. 2012; 5: 242-249
Köttgen A et al, Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2012 Dec 23. [Epub ahead of print] PMID: 23263486.
Liu F, van der Lijn F, Schurmann C, Zhu G, Chakravarty MM, et al. (2012) A Genome-Wide Association Study Identifies Five Loci Influencing Facial Morphology in Europeans. PLoS Genet 8(9): e1002932. doi:10.1371/journal.pgen.1002932
Lu X, et al. Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet. 2012 Jul 1;44(8):890-4 Luciano M et al, Longevity candidate genes and their association with personality traits in the elderly. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 159B(2): 192-200 (2012)
Ivliev AE, ’t Hoen PA, van Roon WM, Peters DJ, Sergeeva MG. Exploring the Transcriptome of Ciliated Cells Using In Silico Dissection of Human Tissues. PLoS One. 2012;7(4):e35618. Epub 2012 Apr 25.
Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium. Collaborators: Ripke S et al, A mega-analysis of genome-wide association studies for major depressive disorder. Molecular Psychiatry, Apr 3 [Epub ahead of print]"
Malley JD, Kruppa J, Dasgupta A, Malley KG, Ziegler A, Probability Machines: Consistent Probability Estimation Using Nonparametric Learning Machines, Methods Inf Med. 2012 January 10; 51(1): 74-81. Published online 2011 September 14.
Mangino M et al, Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. Hum Mol Genet 2012 Dec 15;21(24):5385-94. PMID: 23001564; PMCID: PMC3510758.
Manning AK et al., Discovery of genetic variants implicated in insulin resistance through novel application of a genome-wide approach that accounts for body mass index and SNP by body mass index interaction on fasting glycemic traits. Nat Genet. 2012 May 13;44(6):659-69. doi: 10.1038/ng.2274.
Mastrokolias A, den Dunnen JT, van Ommen GB, 't Hoen PA, van Roon-Mom WM. Increased sensitivity of next generation sequencing-based expression profiling after globin reduction in human blood RNA. BMC Genomics. 2012 Jan 18;13:28.
Middelberg et al., Loci affecting gamma-glutamyl transferase in adults and adolescents show age x snp interaction and cardiometabolic disease associations, Human Molecular Genetics, Jan 15;21(2):446-55.2012 [Epub 2011 Oct 18. ]
Moayyeri A, Hammond CJ, Valdes AM, Spector TD. Cohort Profile: TwinsUK and Healthy Ageing Twin Study. Int J Epidemiol. 2012 Jan 9. [Epub ahead of print] PubMed PMID: 22253318
Morris AP et al, Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012 Sep;44(9):981-90. doi: 10.1038/ng.2383. Epub 2012 Aug 12.
Murtagh, MJ et al, Navigating the perfect [data] storm. Norsk Epidemiologi 2012; 21(2), 203-209.
Mustelin L et al, Genetic influences on physical activity in young adults: a twin study. Med Sci Sports Exerc. 2012 Jul;44(7):1293-301. doi: 10.1249/MSS.0b013e3182479747.
Morales E, Bustamante M, Vilahur N, Escaramis G, Montfort M, de Cid R, Garcia-Esteban R, Torrent M, Estivill X, Grimalt JO, Sunyer J. DNA Hypomethylation at ALOX12 is Associated with Persistent Wheezing in Childhood. Am J Respir Crit Care Med. 2012 Feb 9. [Epub ahead of print] PMID:22323304
O'Reilly PF, Hoggart CJ, Pomyen Y, Calboli FC, Elliott P, Jarvelin MR, Coin LJ. MultiPhen: Joint Model of Multiple Phenotypes Can Increase Discovery in GWAS. PLoS ONE 2012; 7(5): e34861. doi:10.1371/journal.pone.0034861 Epud 2012 May2
Pattaro C et al., Genome-wide association and functional follow-up reveals new Loci for kidney function. PLoS Genet. 2012 Mar;8(3):e1002584. Epub 2012 Mar 29.
Petersen AK et al., Genetic associations with lipoprotein subfractions provide information on their biological nature .Hum Mol Genet. 2012 Mar 15;21(6):1433-43. Epub 2011 Dec 8.
Perry, JR et al. Stratifying type 2 Diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet. 2012 May;8(5):e1002741. Epub 2012 May 31.
Peyrot WJ et al, Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. Journal of Affective Disorders - Sep 26. doi: 10.1016/j.jad.2012.08.044 (2012)
Ramasamy A et al, Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA. PLoS One. 2012;7(9):e44008. PMID: 23028483; PMCID: PMC3461045.
Rhodes B, Fürnrohr BG, Roberts AL, Tzircotis G, Schett G, Spector TD, Vyse TJ. The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes. Ann Rheum Dis. 2012 Aug 8. [Epub ahead of print]
Sandholm N et al, New susceptibility loci associated with kidney disease in type 1 diabetes. PLoS Genet 2012 Sep;8(9):e1002921. PMID: 23028342; PMCID: PMC3447939.doi: 10.1371/journal.pgen.1002921. Epub 2012 Sep 20.
Scott RA et al, Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet. 2012 Sep;44(9):991-1005. doi: 10.1038/ng.2385. Epub 2012 Aug 12.
Service SK et al, A genome-wide meta-analysis of association studies of Cloninger's Temperament Scales. Transl Psychiatry 2012 May 15;2:e116. PMID: 22832960; PMCID: PMC3365256.
Stein JL et al, Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet. 2012; 44(5): 552-561
Stolk L et al., Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nat Genet. 2012 Jan 9;44(3):260-8.
Stoltenberg C et al, From Biobanks for health to Biobank Norway. Norsk Epidemiologi 2012; 21 (2): 127-132
Surakka I et al, A Genome-Wide Association Study of Monozygotic Twin-Pairs Suggests a Locus Related to Variability of Serum High-Density Lipoprotein Cholesterol.Twin Res Hum Genet. 2012 Oct 3:1-9. [Epub ahead of print]
Taal HR et al., Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012 Apr 15;44(5):532-8. doi: 10.1038/ng.2238.[Epub ahead of print]
Terracciano A et al, Meta-analysis of genome-wide association studies identifies common variants in CTNNA2 associated with excitement-seeking. Translational Psychiatry 18(1):e49 (2012)
The CARDIoGRAMplusC4D Consortium, Deloukas P et al., Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2012 Dec 2. doi: 10.1038/ng.2480. [Epub ahead of print]
Traylor M et al, Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 2012 Nov;11(11):951-62. PMID: 23041239; PMCID: PMC3490334.
Tsoi LC et al, Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.Nat Genet. 2012 Dec;44(12):1341-8. doi: 10.1038/ng.2467. Epub 2012 Nov 11.
Tyrrell J et al, Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight. Hum Mol Genet. 2012 Dec 15;21(24):5344-58. doi: 10.1093/hmg/dds372. Epub 2012 Sep 5.
van der Harst P et al, 75 genetic loci influencing the human red blood cell. Nature 492;369-75,2012). doi: 10.1038/nature11677. Epub 2012 Dec 5.
van Koolwijk LME et al, Common Genetic Determinants of Intraocular Pressure and Primary Open-Angle Glaucoma. PLoS Genet 2012; 8(5): e1002611. doi:10.1371/journal.pgen.1002611
Verhoeven VJ et al, Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Hum Genet. 2012 Sep;131(9):1467-80. doi: 10.1007/s00439-012-1176-0. Epub 2012 Jun 5.
Verweij KJ et al, Maintenance of genetic variation in human personality: testing evolutionary models by estimating heritability due to common causal variants and investigating the effect of distant inbreeding.Evolution. 2012 Oct;66(10):3238-51. doi: 10.1111/j.1558-5646.2012.01679.x. Epub 2012 May 21.
Vishram JKK et al, on behalf of the MORGAM Project. Impact of age on the importance of systolic and diastolic blood pressure for stroke risk: The MOnica, Risk, Genetics Archiving and Monograph (MORGAM) Project. Hypertension;60:1117-1123,2012..
Würtz P et al, Metabolic Signatures of Insulin Resistance in 7,098 Young Adults. Diabetes. 2012 Jun;61(6):1372-80. doi: 10.2337/db11-1355. Epub 2012 Apr 17.
Yang J et al, FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012 Oct 11;490(7419):267-72. doi: 10.1038/nature11401. Epub 2012 Sep 16. [Epub ahead of print]
2011
Ahluwalia, TS, Lindholm, E, Groop, LC. Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes. Diabetologia 2011;54(9), 2295-302
Almgren P, Lehtovirta M, Isomaa B, Sarelin L, Taskinen MR, Lyssenko V, Tuomi T, Groop L, for the Botnia Study Group. Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study. Diabetologia 2011; 54(11), 2811-19
Amin N et al., Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM. Mol Psychiatry. 2011 Aug 30. doi: 10.1038/mp.2011.101.
Anvar S. Yahya, Tucker Allan, Vinciotti Veronica, Venema Andrea, van Ommen Gertjan B., van der Maarel, Silvère M. Raz Vered,’t Hoen Peter A.C., Interspecies translation of disease networks increases robustness and predictive accuracy. PLoS Computational Biology 7: e1002258 (2011)
Barker A et al., Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes. 2011 Jun;60(6):1805-12. Epub 2011 Apr 22.
Berglund E, Kiialainen A, Syvänen A-C. Next Generation Sequencing Technologies and Applications for Human Genetic History and Forensics. Investigative Genetics 2:23, 2011, PMC3267688
Bodenant M, Kuulasmaa K, Wagner A, Kee F, Palmieri L, Ferrario MM, Montaye M, Amouyel P, Dallongeville J; for the MORGAM Project. Measures of abdominal adiposity and the risk of stroke: The MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Study. Stroke 2011;42:2872-2877.
Budin-Ljosne I, Tasse AM, Knoppers BM, Harris JR.Bridging consent: From toll bridges to lift bridges? BMC Med Genomics. 2011 Oct 4;4(1):69. (ENGAGE led)]
Chambers JC et al., Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet. 43(11):1131-8, 2011
Day-Williams AG et al., A variant in MCF2L is associated with osteoarthritis. Am J Hum Genet. 2011 Sep 9;89(3):446-50. Epub 2011 Aug
Dehghan A et al., Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation 2011 Feb 22; 123(7)731-8
Demirkan et al.. Genetic architecture of circulating lipid levels. European Journal of Human Genetics 2011 July; 19, 813-819. doi:10.1038/ejhg.2011.21 (ENGAGE led)
Desrivières S, Lourdusamy A, Müller C, Ducci F, Wong CP, Kaakinen M, Pouta A, Hartikainen AL, Isohanni M, Charoen P, Peltonen L, Freimer N, Elliott P, Jarvelin MR, Schumann G., Glucocorticoid receptor (NR3C1) gene polymorphisms and onset of alcohol abuse in adolescents.Addict Biol. 2011 Jul;16(3):510-3. Epub 2010 Aug 23
Erdmann J et al., Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23. Eur Heart J 2011; 32, 158-168 [Epub 2010 Nov 18]
Ferreira MA et al., Identification of IL6R and chromosome 11q13.5 as risk loci for asthma. Lancet. 78(9795): 1006-14, 2011
Fortier I, Doiron D, Little J, Ferretti V, L’heureux F, Stolk RP, Knoppers BM, Hudson TJ, Burton PR; on behalf of the International Harmonization Initiative. Is rigorous retrospective harmonization possible? Application of the DataSHaPER approach across 53 large studies. Int J epidemiol. 2011 Jul 30
Gervin K, Hammerø M, Akselsen HE, Moe R, Nygård H, Brandt I, Gjessing HK, Harris JR, Undlien DE, Lyle R. Extensive variation and low heritability of DNA methylation identified in a twin study. Genome Res. 2011 Nov;21(11):1813-21. Epub 2011 Sep 26.
Gieger et al. New gene functions in megakaryopoiesis and platelet formation.. Nature. 2011 Nov 30. doi: 10.1038/nature10659. [Epub ahead of print]
Gostev M et al., SAIL—a software system for sample and phenotype availability across biobanks and cohorts. Bioinformatics. 2011 Feb15;27(4):589-91. doi: 10.1093/bioinformatics/btq693 (ENGAGE led)
Hertel JK, Johansson S, Sonestedt E, Jonsson A, Lie RT, Platou CG, Nilsson PM, Rukh G, Midthjell K, Hveem K, Melander O, Groop L, Lyssenko V, Molven A, Orho-Melander M, Njølstad PR. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes. 2011 May;60(5):1637-44. Epub 2011 Mar 11.
International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret et al., Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature Volume: 478, Pages: 103–109 Date published: (06 October 2011) DOI: doi:10.1038/nature10405
Jacquemont S et al., Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locus. Nature. 2011 Aug 31[Epub ahead of print] PMID: 21881559
Jelier R et al., Literature-aided interpretation of gene expression data with the weighted global test. Briefings in Bioinformatics. 2011 Feb9 [Epub ahead of print].; doi: 10.1093/bib/bbq082
Kiialainen A, Karlberg O, Ahlford A, Sigurdsson S, Lindblad-Toh K, Syvänen AC. Performance of microarray and liquid based capture methods for target enrichment for massively parallel sequencing and SNP discovery. PLoS One. 2011 Feb 9;6(2):e16486.
Kilpeläinen TO et al., Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Med. 2011 Nov;8(11):e1001116. Epub 2011 Nov 1.
Kilpeläinen TO et al., Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011 Jun 26;43(8):753-60. doi:10.1038/ng.866. PubMed PMID: 21706003
Knoppers BM, Harris JR, Burton PR, Murtagh M, Cox D, Deschenes M, Fortier I, Hudson TJ, Kaye J, Lindpainter k. From genomic databases to translation: a call to action. J Med Ethics. 2011 May 26. [Epub ahead of print] PMID:21617164 (ENGAGE led)
Knoppers et al.. Towards a data sharing Code of Conduct for international genomic research. Genome Medicine 2011, 3:46 doi:10.1186/gm262 (ENGAGE led)
Knoppers BM, Hudson TJ. The art and science of biobanking. Hum Genet. 2011 Sep; 130(3):329-32. Epub 2011 Jul 21.
Kraja AT et al.,A bivariate genome-wide approach to metabolic syndrome: STAMPEED Consortium. Diabetes 2011;60:1329-1339
Kutalik Z et al., Genome-wide association study identifies two loci strongly affecting transferrin glycosylation. Hum Mol Genet. 2011 Sep 15;20(18):3710-7. Epub 2011 Jun 10. PubMed PMID: 21665994; PubMed Central PMCID: PMC3159549.
Ligthart L et al., Meta-analysis of genome-wide association for migraine in six population-based European cohorts. Eur J Hum Genet. 2011 Aug;19(8):901-7. doi: 10.1038/ejhg.2011.48. Epub 2011 Mar 30.
Lyssenko V, Eliasson L, Kotova O et al. Pleiotropic effects of a variant in the GIPR gene on islet function and risk of type 2 diabetes. Diabetes 60;2424-33,2011 PMC3161325
Maugeri N, Powell J, 't Hoen PA, de Geus EJ, Willemsen G, Kattenberg M, Henders AK, Wallace L, Penninx B, Hottenga JJ, Medland SE, Saviouk V, Martin NG, Visscher PM, van Ommen GJ, Frazer IH, Boomsma DI, Montgomery GW, Ferreira MA. LPAR1 and ITGA4 regulate peripheral blood monocyte counts. Human Mutation, 32(8):873-6, 2011
Min JL, Taylor JM, Richards JB, Watts T, Pettersson FH, Broxholme J, Ahmadi KR, Surdulescu GL, Lowy E, Gieger C, Newton-Cheh C, Perola M, Soranzo N, Surakka I, Lindgren CM, Ragoussis J, Morris AP, Cardon LR, Spector TD, Zondervan KT. The Use of Genome-Wide eQTL Associations in Lymphoblastoid Cell Lines to Identify Novel Genetic Pathways Involved in Complex Traits. PLoS One. 2011;6(7):e22070. Epub 2011 Jul 15.
Murtagh MJ, Demir I, Harris JR, Burton PR. Realizing the promise of population biobanks: a new model for translation. Hum Genet. 2011 Sep;130(3):333-45 PMID: 21706184
Mustelin L. et al., Genetic influences on physical activity in young adults. A twin study. J Appl Physiol. 2011 Mar;110(3):681-6. Epub 2010 Dec 30.
Nalls MA et al., Multiple loci are associated with white blood cell phenotypes. PLoS Genet. 2011 Jun;7(6):e1002113. Epub 2011 Jun 30.
Obeidat M et al., A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample. PLoS One. 2011;6(5):e19382. Epub 2011 May 20
Paternoster L, et al., the EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium, Weidinger S. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet. 2011 Dec 25;44(2):187-192.
Pietiläinen OP, Rehnström K, Jakkula E, Service SK, Congdon E, Tilgmann C, Hartikainen AL, Taanila A, Heikura U, Paunio T, Ripatti S, Jarvelin MR, Isohanni M, Sabatti C, Palotie A, Freimer NB, Peltonen L. Phenotype mining in CNV carriers from a population cohort. Hum Mol Genet. 2011 Jul 1;20(13):2686-95. Epub 2011 Apr 19
Schumann G et al.. Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption. PNAS. 2011 April; 108(17):7119-24. doi: 10.1073/pnas.1017288108
Small KS et al., Identification of an imprinted master trans-regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet. 2011 Jun;43(6):561-4. Epub 2011 May 15.
Smith NL, et al., Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation. 2011 May 3;123(17):1864-72. Epub 2011 Apr 18
Soler Artigas M, et al., Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.Nat Genet. 2011 Sep 25;43(11):1082-90. doi: 10.1038/ng.941.
Soler Artigas M et al.,SpiroMeta Consortium. Effect of Five Genetic Variants Associated with Lung Function on the Risk of Chronic Obstructive Lung Disease, and Their Joint Effects on Lung Function. Am J Respir Crit Care Med. 2011 Oct 1;184(7):786-95.
Sovio U et al., Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet. 2011 Feb;7(2):e1001307. Epub 2011 Feb 17
Strawbridge RJ*, Dupuis J*, Prokopenko I*, Barker A*, Ahlqvist E* et al., Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes 2011:60:2624-2634. PMID: 21873549
Suhre et al., Human metabolic individuality in biomedical and pharmaceutical research. Nature Volume: 477, Pages: 54–60 Date published: (01 September 2011) DOI: doi:10.1038/nature10354
Surakka I, Isaacs A et al.. A Genome-Wide Screen for Interactions Reveals a New Locus on 4p15 Modifying the Effect of Waist-to-Hip Ratio on Total Cholesterol. PLoS Genetics 2011 Oct;7(10):e1002333 (Epub 2011 Oct 20) doi: 10.1371/journal.pgen.1002333 (ENGAGE led)
Tassé AM. The Return of Results of Deceased Research Participants. Journal of Law, Medicine and Ethics 2011(39):4, 621-630.
Tassé AM. Biobanking and Deceased Persons, Hum Genet 2011 (130) 415-423.
Thanabalasingham G, Shah N, Vaxillaire M, Hansen T, Tuomi T, Gasperikova D, Szopa M, Tjora E, James TJ, Kokjo P, Loiseleur F, Andersson E, Gaget S, Isomaa B, Nowak N, Raeder H, Stanik J, Njolstad PR, Malecki MT, Klimes I, Groop L, Pedersen O, Froguel P, McCarthy MI, Gloyn AL, Owen KR. A large multi-centre European study validates high-sensitivity C-reactive protein (hsCRP) as a clinical biomarker for the diagnosis of diabetes subtypes. Diabetologia 2011 Aug 4 (Epub ahead of print) PMID:21814873
Vangjeli C. et al., A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project., J Renin Angiotensin Aldosterone Syst. 2011 Apr 13
Wain et al., Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics Volume: 43, Pages: 1005–1011 Year published: (2011) DOI: doi:10.1038/ng.922
Zhai G. et al.,. Eight Common Genetic Variants Associated with Serum DHEAS Levels Suggest a Key Role in Ageing Mechanisms. PLoS Genet. 2011 Apr;7(4):e1002025. Epub 2011 Apr 14.
2010
Blankenberg et al. Contribution of 30 biomarkers to 10-year cardiovascular risk estimation in 2 population cohorts: the MONICA, risk, genetics, archiving, and monograph (MORGAM) biomarker project. Circulation. 2010 Jun 8;121(22):2388-97. Epub 2010 May 24.
Chambers et al. Genetic loci influencing kidney function and chronic kidney disease. Nat Genet. 2010 May;42(5):373-5. Epub 2010 Apr 11.
Codd et al. Common variants near TERC are associated with mean telomere length. Nat Genet. 2010 Mar;42(3):197-9. Epub 2010 Feb 7.
Dupuis et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Jan 17.
Elks CE et al., Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet. 2010 Dec;42(12):1077-85.
Freathy et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet. 2010 May;42(5):430-5. Epub 2010 Apr 6.
Heid IM et al.. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010 Oct 10. [Epub ahead of print]
Illig et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010 Feb;42(2):137-41. Epub 2009 Dec 27.
Ingelsson et al. Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans. Diabetes (2010) 59; 1266-75 Feb 25. [Epub ahead of print]
Lango Allen H, et al., Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Sep 29. [Epub ahead of print]
Milani et al. DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood. 2010 Feb 11;115(6):1214-25. Epub 2009 Nov 25.
Naukkarinen et al. Use of genome-wide expression studies to mine the "gray zone" of GWA studies leads to novel candidate obesity genes. PLoS Genet. 2010 Jun 3;6(6):e1000976. (ENGAGE led publication)
Owen KR, et al..Assessment of high-sensitivity C-reactive protein levels as diagnostic discriminator of maturity-onset diabetes of the young due to HNF1A mutations. Diabetes Care. 2010 Sep;33(9):1919-24. Epub 2010 Aug 19.
Pillas et al. Genome-wide association study reveals multiple loci associated with primary tooth development. PLoS Genetics 2010;6:e1000856.
Repapi et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet. 2010 Jan;42(1):36-44. Epub 2009 Dec 13. PubMed PMID: 20010834.
Saxena et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010 Feb;42(2):142-8. Epub 2010 Jan 17.
Saccone et al.. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet. 2010 Aug 5;6(8). pii: e1001053.
Solveig Gretarsdottir, et al., Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm. Nat Genet. 2010 Aug;42(8):692-7. Epub 2010 Jul 11.
Soranzo N, et al., Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways.Diabetes. 2010 Sep 21. [Epub ahead of print]
Speliotes EK et al.. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Oct 10. [Epub ahead of print]
Tassé AM, Budin-Ljøsne I, Knoppers BM, Harris JR. Retrospective access to data: the ENGAGE consent experience. Eur J Hum Genet. 2010 Mar 24. [Epub ahead of print]
Teslovich et al.. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 August; 466(7307):707-13
Thorgeirsson et al. Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior and the risk of lung cancer. Nat Genet 2010;42:448-453.
Voight et al.. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet. 2010 Jul; 42: 579–589
Wang et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet. 2010 Jun 9. [Epub ahead of print]
Walters et al. A novel highly-penetrant form of obesity due to a 740kb deletion on chromosome 16p11. Nature 2010;463:671-675. PMID: 20130649
Waterworth et al., Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2010 Sep 23. [Epub ahead of print]
Widén et al. Distinct variants at LIN28B influence growth in height from birth to adulthood. Am J Hum Genet. 2010 May 14;86(5):773-82. Epub 2010 Apr 15.
2009
Aulchenko, Ripatti et al. Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Nature Genetics 41, 47 - 55 (2009) Published online: 7 December 2008 (ENGAGE led publication)
Bartha Maria Knoppers. Genomics and policymaking: from static models to complex systems? Human Genetics 2009 May;125(4):375-9. Epub 2009 Feb 28
Chambers et al. Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels. Nature Genetics 41(11), 1161-2 (2009). Published online: 11 October 2009
Coronary Artery Disease Consortium. Large scale association analysis of novel genetic loci for coronary artery disease. Arterioscler Thromb Vasc Biol. 2009 May;29(5):774-80. Epub 2009 Jan 22.
Eleftherohorinou et al. Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases. PLoS One. Nov 30;4(11) (2009).
Erdmann et al. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nature Genetics. 2009 Mar;41(3):280-2. Epub 2009 Feb 8.
Grisoni et al. Lack of association between polymorphisms of the IL18R1 and IL18RAP genes and cardiovascular risk: the MORGAM Project. BMC Med Genet. 2009 May 27;10:44.
Inga Prokopenko et al. Variants in MTNR1B fasting glucose levels. Nature Genetics 41, 77 - 81 (2009) Published online: 7 December 2008 | doi:10.1038/ng.290 (ENGAGE led publication)
Iris M. Heid et al., Meta-Analysis of the INSIG2 Association with Obesity Including 74,345 Individuals: Does Heterogeneity of Estimates Relate to Study Design? Plos Gen 2009;5:e1000694
Jonsson et al. A variant in the KCNQ1 gene predicts future type 2 diabetes and mediates impaired insulin secretion. Diabetes. 2009 Oct;58(10):2409-13. Epub 2009 Jul 7.
Karvanen et al. The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts. Genet Epidemiol. 2009;33:237-246.
Kolz et al. Meta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations. PLoS Genet. 2009 Jun;5(6):e1000504. Epub 2009 Jun 5.
Krestyaninova et al. A System for Information Management in BioMedical Studies--SIMBioMS. Bioinformatics. 2009 Oct 15;25(20):2768-9. Epub 2009 Jul 24.
Menezes et al. Integrated analysis of DNA copy number and gene expression microarray data using gene sets. BMC Bioinformatics 10:203 (2009)
Newton-Cheh et al. Genome-wide association study identifies eight loci associated with blood pressure. Nature Genetics 41, 666 - 676 (2009). 2009 May 10. [Epub ahead of print]
Nelis M, Esko T et al. Genetic Structure of Europeans: a view from the North-East. PLoS ONE 4(5): e5472
Pulizzi et al. Interaction between prenatal growth and high-risk genotypes in the development of type 2 diabetes. Diabetologia. 2009 May;52(5):825-9. Epub 2009 Feb 19.
Richards et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009 Dec;5(12):e1000768. Epub 2009 Dec 11.
Saarela O, Kulathinal S, Karvanen J. Joint analysis of prevalence and incidence data using conditional likelihood. Biostatistics. 2009 Jul;10(3):575-87. Epub 2009 May 20.
Sabatti et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. Nature Genetics 41, 35 - 46 (2009). Published online: 7 December 2008
Soranzo et al. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nature Genetics 41(11), 1182- 90 (2009). Published online: 11 October 2009
Sovio U et al. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. PLoS Genet. 2009 Mar;5(3):e1000409. Epub 2009 Mar 6.
Thorleifsson G et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nature Genetics 41, 18 - 24 (2009). Published online: 14 December 2008
Valeriya et al. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nature Genetics 41, 82 - 88 (2009) Published online: 7 December 2008
Willer et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics 41:25-34 (2009)
2008
Grisoni M-L et al. Haplotypic analysis of tag SNPs of the interleukin-18 gene in relation to cardiovascular disease events: the MORGAM Project. European Journal of Human Genetics. 2008 Dec;16(12):1512-20. Epub 2008 Jul 16
Kristiansson K, Naukkarinen J, Peltonen L. Isolated populations and complex disease gene identification. Genome Biol. 2008;9(8):109. doi: 10.1186/gb-2008-9-8-109. Epub 2008 Aug 26.
Pantano L, Armengol L, Villatoro S, Estivill X. ProSeeK: a web server for MLPA probe design. BMC Genomics. 2008 Nov 28;9:573. doi: 10.1186/1471-2164-9-573.
Prokopenko I, McCarthy MI, Lindgren CM. Type 2 diabetes: new genes, new understanding. Trends Genet. 2008 Dec;24(12):613-21. doi: 10.1016/j.tig.2008.09.004. Epub 2008 Oct 25. Review.
Saarela O et al. Nested case-control data utilized for multiple outcomes: a likelihood approach and alternatives. Stat Med. 2008 Dec 10;27(28):5991-6008.
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